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KMID : 0363019750050010023
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Journal of Korean Academy of Periodontology
1975 Volume.5 No. 1 p.23 ~ p.28
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The effects of ginseng and diazepam on Lidocaine toxicity
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Baek Bak-Sam
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Abstract
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Water and methanol extracts were obtained and crude saponin fraction fractionated from Panax Ginseng and their effects in comparison with Diazepam on 0.6% and 2.0% lidocaine and procaine toxicity were observed in aggregated mice. at the same fime, the effect of crude saponin fraction on pentobarbital sleeping time was observed. The duration of righting reflex-loss induced by pentobarbital was markedly prolonged by the pretreatment of large dose(100mg/Kg) of crude saponin fraction. Large dose of Ginseng water extract, methanol extract and crude saponin fraction increased 0.6% lidocaine toxicity, while dereased 2. 0% lidocaine toxicity. Diazepam(l. 0mg/Kg or 5.0mg/Kg) increased 0.6% lidocaine toxicity, while decreased 2. 0lidocaine toxicity.
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KEYWORD
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